Backed by the singles "Stupid Kid" and "Private Eye", From Here to Infirmary significantly increased the band's exposure, and its follow-up, Good Mourning (2003), charted highly on the Billboard 200. Good Mourning marked the recording debut of current drummer Derek Grant. In 2005, the band released Crimson which expanded upon the band's punk rock influences, with prominent overdubs and additional instrumentation, and continued with this direction on Agony & Irony (2008), which was released on Epic Records.
In 2010, the band released This Addiction on its own label Heart & Skull and Epitaph. Recorded in the band's home town of Chicago, with early producer Matt Allison, the album was a conscious effort by the band to return to their punk rock roots; it became the highest charting album of their career, debuting on the Billboard 200 at No. 11. In 2011, the band celebrated its 15-year anniversary with the release of Damnesia, which featured new, acoustic-based recordings of songs from across the band's career. The band's eighth studio album, My Shame Is True, was released on April 2, 2013.